Comorbidities as risk factors for migraine onset: A systematic review and three-level meta-analysis.

ABSTRACT:

Introduction

Migraine is a debilitating neurological disease with a multifaceted pathophysiology. Pre-existing comorbidities may influence the risk of developing migraine. This review and meta-analysis aim to present a comprehensive overview of the known comorbidities predisposing individuals to new migraine onset, thereby improving our understanding of the respective diseases' interactions.

Methods

A systematic search of PubMed and EMBASE identified studies on pre-existing comorbidities as risk factors for new migraine onset. We performed three-level meta-analyses employing restricted maximum likelihood estimation to calculate pooled risk ratios (pRR). Subgroup and sensitivity analyses were conducted to assess the robustness of the data. Risk of bias (RoB) was assessed with

SUBMITTER: Terhart M 

PROVIDER: S-EPMC11880117 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature