Involvement of BK Channels and Ryanodine Receptors in Salicylate-induced Tinnitus.

ABSTRACT: Neural hyperexcitability of the central auditory system is a key pathological characteristic of tinnitus, but its underlying molecular mechanisms remain elusive. The large-conductance Ca²⁺-activated K⁺ channel (BK) plays a crucial role in down- or upregulating neuronal activity. This study aims to investigate the role of BK channels in mediating tinnitus-associated neural hyperexcitability and elucidate the mechanisms behind it. Immunofluorescent staining revealed extensive expression of the BK channels on neurons within the central auditory system of rats. After long-term systemic administration of salicylate, a stable tinnitus inducer, we observed a significant change in the expression levels of BKα and β4 subunits in the rat central auditory system. In addition, sa

SUBMITTER: Shi W 

PROVIDER: S-EPMC11880135 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature