Oscillatory DeltaC Expression in Neural Progenitors Primes the Prototype of Forebrain Development.

ABSTRACT: Notch signaling plays a pivotal role in regulating various developmental processes, particularly in controlling the timing of neuronal production within the developing neocortex. Central to this regulatory mechanism is the oscillatory pattern of Delta, which functions as a developmental clock modulator. Its deficiency profoundly impairs mammalian brain formation, highlighting its fundamental role in brain development. However, zebrafish carrying a mutation in the functional ortholog DeltaC (dlc) within their functional ortholog exhibit an intact forebrain structure, implying evolutionary variations in Notch signaling within the forebrain. In this study, we unveil the distinct yet analogous expression profiles of Delta and Her genes in the developing vertebrate forebrain. Specifically, for

SUBMITTER: Nian FS 

PROVIDER: S-EPMC11880136 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature