Potential Predictive Value of Platelet Distribution Width for Functional Outcome After Ischemic Stroke.

ABSTRACT: Complete blood cell count (CBC) is the most common and readily available laboratory test in clinical practice. The relationships of some CBC indices with ischemic stroke have been reported in observational studies; however, the causal direction is not specified. This study aimed to explore the causal relationships between CBC indices and the modified Rankin Scale (mRS) score at 3 months after ischemic stroke. Genetic associations of 22 blood cell traits were obtained from the UK Biobank database (n = 350,475). The outcome data for ischemic stroke were obtained from the Genetic Ischemic Stroke Functional Outcome (GISCOME) network (n = 6021). We implemented two-sample Mendelian randomization (TSMR) and several complementary analyses to assess the causal association between blood traits and u

SUBMITTER: Shen T 

PROVIDER: S-EPMC11880176 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature