Impact of levetiracetam on direct oral anticoagulant level and outcomes among older Asian patients with atrial fibrillation.

ABSTRACT:

Objective

This purpose of this study is to analyze the influence of levetiracetam (LEV) on direct oral anticoagulant (DOAC) exposure and its implications for clinical outcomes.

Methods

This investigation comprised a retrospective cohort study utilizing the integrated medical database and a prospective observational study conducted in a tertiary hospital. Patients aged >65 years with atrial fibrillation and undergoing DOAC therapy were included and were categorized as LEV users and non-users based on LEV exposure status. In retrospective cohort, clinical outcomes between LEV users and non-users were compared, included ischemic stroke or transient ischemic attack (IS/TIA), systemic thromboembolism (STE) and major bleeding. In prospective cohort, DOAC trough concentration was m

SUBMITTER: Huang YT 

PROVIDER: S-EPMC11880207 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature