Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA <sub><i>A</i></sub> receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells.
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ABSTRACT: Islet amyloid polypeptide (IAPP, amylin) is a peptide hormone that plays an important role in glucose homeostasis but has been implicated in the pathophysiology of type 2 diabetes and Alzheimer's disease. However, its effect on neurotransmission in the hippocampus remains poorly understood. Here, we investigated the impact of non-amyloidogenic rodent IAPP (rIAPP) on GABA A receptor-mediated neuronal inhibition in mouse dorsal and ventral hippocampal dentate gyrus (DG) granule cells. Using whole-cell patch-clamp recordings, we showed that rIAPP selectively enhanced both GABA-activated spontaneous and miniature inhibitory postsynaptic currents (sIPSCs and mIPSCs) in ventral, but not dorsal, hippocampal DG granule cells. The effect of rIAPP on sIPSCs was completely abolished
SUBMITTER: Netsyk O
PROVIDER: S-EPMC11880208 | biostudies-literature | 2025
REPOSITORIES: biostudies-literature
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