Cytokine profiles and CD4 counts in HIV-positive individuals with cysticercosis: implications for sex-specific immune responses in co-endemic regions of Tanzania.

ABSTRACT:

Introduction

The interplay between HIV and Taenia solium cysticercosis in co-endemic regions remains poorly understood, particularly regarding the immune responses but is relevant for an effective treatment strategy. This study aimed to investigate the relationship between peripheral cytokine profiles, CD4⁺ T-cell counts, and cysticercosis infection status in HIV-positive individuals in Tanzania's southern highlands.

Methods

We conducted a cross-sectional study involving 110 HIV-positive individuals. Cysticercosis was diagnosed using antibody and antigen tests, with neurocysticercosis confirmed by CT imaging. CD4 counts and serum cytokine levels (pro- and anti-inflammatory) were analyzed using multivariate regression and MANOVA, including sex-stratified ana

SUBMITTER: Lema YL 

PROVIDER: S-EPMC11880214 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature