Comparing computational times for simulations when using PBPK model template and stand-alone implementations of PBPK models.

ABSTRACT:

Introduction

We previously developed a PBPK model template that consists of a single model "superstructure" with equations and logic found in many physiologically based pharmacokinetic (PBPK) models. Using the template, one can implement PBPK models with different combinations of structures and features.

Methods

To identify factors that influence computational time required for PBPK model simulations, we conducted timing experiments using various implementations of PBPK models for dichloromethane and chloroform, including template and stand-alone implementations, and simulating four different exposure scenarios. For each experiment, we measured the required computational time and evaluated the impacts of including various model features (e.g., number of output variables calc

SUBMITTER: Bernstein AS 

PROVIDER: S-EPMC11880222 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature