Potential efficacy and mechanisms of icariin for the animal model of osteonecrosis of the femoral head.

ABSTRACT:

Introduction

Icariin (ICA), one of the main active components of Epimediumis, is reported to revere osteonecrosis of the femoral head (ONFH). The aim of this study is to further explore the mechanisms and efficacy of ICA in animal models of ONFH and simultaneously analyze methodological issues in the field of researches.

Methods

According to the established search strategy, we searched 14 studies from eight databases from their inception dates to November 2024. The CAMARADES 10-item checklist was utilized to evaluate the methodological quality of the stuies and Rev-Man 5.3 software to analyze differences in outcome indicators.

Results

The quality score for the included articles ranges from 1/10 to 6/10 with an average of 4.5 and the defects in aspects of blindi

SUBMITTER: Xu J 

PROVIDER: S-EPMC11880249 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature