Differential susceptibility effects of the <i>5-HTTLPR</i> and <i>MAOA</i> genotypes on decision making under risk in the Iowa gambling task.

ABSTRACT:

Introduction

The interplay between genetic and environmental factors, as explored through studies of gene-environment interactions (cG×E), has illuminated the complex dynamics influencing behavior and cognition, including decision-making processes. In this study, we investigated the differential susceptibility effects of the 5-HTTLPR and MAOA genotypes on decision-making under risk using the Iowa Gambling Task.

Methods

Data from 264 participants (138 women, 126 men) aged 18-22 years, from the 2015 wave of the Survey of Adolescent Life in Västmanland (SALVe Cohort) was analyzed. Participants provided genetic data including the MAOA and 5-HTTLPR genotypes, and completed the Iowa Gambling Task (IGT) to evaluate decision-making behavior. Parent report

SUBMITTER: Rehn M 

PROVIDER: S-EPMC11880251 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature