Identification and validation of key genes associated with cell senescence in acute myocardial infarction.

ABSTRACT:

Introduction

Cellular senescence can cause heart failure. However, studies on diagnostic markers related to cellular senescence in acute myocardial infarction (AMI) have not been reported. Therefore, this study explores the mechanism of key genes related to cellular senescence in acute myocardial infarction (AMI) through a bioinformatics approach.

Methods

AMI related datasets were obtained from gene expression omnibus (GEO) database, and 3,058 cellular senescence related genes (CSRGs) were extracted from Molecular Signatures Database (MSigDB). First, differentially expressed genes (DEGs) were screened by differential expression analysis,and then Weighted gene co-expression network analysis (WGCNA) was performed to obtained the key module. CSRGs, DEGs and genes in key module

SUBMITTER: Zhao W 

PROVIDER: S-EPMC11880263 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature