The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.

ABSTRACT:

Introduction

Vaccine-related myocarditis is recognized as a rare but important complication, especially after mass-scale mRNA COVID-19 vaccination. Knowledge regarding how to minimize the risk is limited. As NK cells can mediate acute myocarditis after mRNA COVID-19 vaccination and vitamin D may inhibit NK cells via cytokine modulation, we hypothesize that the myocarditis side effect is related to a hypovitaminosis D - mRNA vaccine - hypercytokinemia - NK cell axis, which is amendable to clinical intervention.

Methods

Biochemical, immunophenotypic and genotyping assays were performed to examine vitamin D status and immune profiles in 60 patients who had BNT162b2 vaccine-related acute myocarditis.

Results

A high incidence of hypovitaminosis D (73.3%) was observed in th

SUBMITTER: Tsang HW 

PROVIDER: S-EPMC11880265 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature