RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease.

ABSTRACT: The emerging field of epitranscriptomics is reshaping our understanding of post-transcriptional gene regulation in inflammatory diseases. N⁴-acetylcytidine (ac⁴C), the only known acetylation modification in RNA catalyzed by N-acetyltransferase 10 (NAT10), is known to enhance mRNA stability and translation, yet its role in inflammatory bowel disease (IBD) remains unclear. In this study, we discovered that Nat10 expression correlates with inflammatory and apoptotic pathways in human ulcerative colitis CD4⁺ T cells. Our further analysis revealed that the deficiency of NAT10 led to a disruption of T cell development at steady state, and identified a pivotal role for NAT10 in preserving the pathogenicity of naïve CD4⁺ T cells to induce adoptive transf

SUBMITTER: Li H 

PROVIDER: S-EPMC11880361 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature