NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling.

ABSTRACT: Adult neurogenesis in the hippocampus, involving the generation and integration of new neurons, is essential for behavioral pattern separation, which supports accurate memory recall and cognitive plasticity. Here, we explore the role of the DNA repair protein NEIL3 in adult hippocampal neurogenesis and behavioral pattern separation. NEIL3 is required for efficient proliferation and neuronal differentiation of neonatal NSPCs and adult-born NPCs in the hippocampus following a behavioral pattern separation task. NEIL3-depleted mice exhibited a reduced preference for the novel object location, indicating a deficit in pattern separation. NEIL3-deficient adult-born neurons exhibited a significant reduction in mature-like membrane properties, indicating impaired functional maturation. Interesting

SUBMITTER: Fernandez-Berrocal MS 

PROVIDER: S-EPMC11880487 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature