Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness.

ABSTRACT: Psychological stress causes gut microbial dysbiosis and cancer progression, yet how gut microbiota determines psychological stress-induced tumor development remains unclear. Here we showed that psychological stress promotes breast tumor growth and cancer stemness, an outcome that depends on gut microbiota in germ-free and antibiotic-treated mice. Metagenomic and metabolomic analyses revealed that psychological stress markedly alters the composition and abundance of gut microbiota, especially Akkermansia muciniphila (A. muciniphila), and decreases short-chain fatty acid butyrate. Supplement of active A. muciniphila, butyrate or a butyrate-producing high fiber diet dramatically reversed the oncogenic property and anxiety-like behavior of psychological stress in a murine spontaneous tumor mod

SUBMITTER: Cui B 

PROVIDER: S-EPMC11880501 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature