Family-based genetics identifies association of CUBN, IL1RL1 and PRKN variants with leprosy in Bangladesh.

ABSTRACT: Previous studies have demonstrated the association between the occurrence of leprosy and several host genetic variants that can vary across different ethnic groups and populations. Since leprosy susceptibility genes have not been investigated in detail in the Bangladeshi population that still includes highly endemic areas, we here studied known associations between leprosy and 13 genetic markers located in 11 genes in a leprosy endemic area in Bangladesh for which an association with leprosy was previously found in an isolated former leprosy colony in the Brazilian Amazon. For this study, a family-based analysis using 60 parent-affected child trios was performed, followed by a case-control study of 210 leprosy patients and 189 healthy controls from the same area (endemic controls). Genotyp

SUBMITTER: Dos Santos AM 

PROVIDER: S-EPMC11880505 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature