Assessing the impact of revising MenACWY vaccination schedule for adolescents in the United States: a modelling study.

ABSTRACT:

Background

The current recommendation for MenACWY vaccination against invasive meningococcal disease (IMD) in the United States (US) includes two doses: the first dose at ages 11-12 and a booster dose at age 16. The Advisory Committee on Immunization Practices has proposed options for revising this schedule by either eliminating the first dose or adjusting the timing of the first dose to age 15 and the booster to ages 17-18. The impact of these alternative schedules on IMD incidence remains undetermined.

Methods

We developed an age-stratified, agent-based Monte-Carlo simulation model of meningococcal transmission dynamics, parameterised with US age demographics, to assess the impact of the proposed changes to the MenACWY vaccination schedules. Excluding serogroup A, absent i

SUBMITTER: Shoukat A 

PROVIDER: S-EPMC11880592 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature