Fractures in Hereditary Neuromuscular Disorders: Frequency, Risk Factors, and Implications.

ABSTRACT:

Background

Hereditary neuromuscular disorders (NMD) are associated with compromised bone health and elevated fracture risk, though data are largely lacking.

Objective

This study aimed to assess the prevalence and risk factors of fractures in hereditary NMD.

Methods

We conducted a retrospective study in a cohort of adult patients with diverse hereditary NMD, using data from electronic medical records.

Results

Among 469 patients, 505 fractures were recorded, with 5.5% of patients experiencing a fracture within the past year. In the 10 years preceding study inclusion, 31.1% of all patients sustained at least one fracture. The fracture rate was 47.3/1000 patient-years. Fracture incidence was highest in the second decade of life and the first five years after sympto

SUBMITTER: Opsomer M 

PROVIDER: S-EPMC11880628 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature