MiRNA-34a-5p inhibits chicken myoblasts proliferation and differentiation via NOTCH1 inhibition.

ABSTRACT: The growth performance of chickens contributes to the sustainable development of the broiler industry, and skeletal muscle development is particularly crucial for chicken production. MicroRNAs (miRNAs) are noncoding RNAs that can participate in the regulation of many biological processes. MiR-34a-5p is a miRNA closely related to chicken skeletal muscle growth and development. However, the specific role of miR-34a-5p in chicken skeletal muscle development remains unknown. Characteristic analysis revealed that the structures and functions of miR-34a-5p from 14 species were similar. Transmembrane domain, hydropathicity/hydrophobicity, and signal peptide analyses of the chicken NOTCH1 protein demonstrated that NOTCH1 may participate in cellular life processes. Motif identification and gene str

SUBMITTER: Ling X 

PROVIDER: S-EPMC11880695 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature