Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohort.

ABSTRACT:

Objective

Risk prediction models are used to determine eligibility for targeted lung cancer screening. However, prospective data regarding model performance in this setting are limited. Here we report the performance of the PLCO_m2012 risk model, which calculates 6 year lung cancer risk, in a cohort invited for lung cancer screening in a socioeconomically deprived area.

Methods and analysis

Calibration (expected/observed (E/O) lung cancer diagnoses over 6 years) and discrimination (area under the receiver operating characteristic curve) of PLCO_m2012 and other models was performed in Manchester Lung Health Check (M-LHC) participants, where PLCO_m2012 ≥1.51% was used prospectively to determine screening eligibility. Lung cancers diagnosed by any

SUBMITTER: Goodley P 

PROVIDER: S-EPMC11880782 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature