Bladder drugs and risk of dementia: Danish nationwide active comparator study.

ABSTRACT:

Objective

To assess the association between cumulative use of anticholinergic bladder drugs and risk of all cause dementia compared with non-use and use of the β3 agonist bladder drug, mirabegron.

Design

Danish nationwide active comparator study.

Setting

National Danish registries, 1 January 2000 to 31 December 2022.

Participants

1 29 254 individuals with dementia were matched by age and sex to 646 270 controls without dementia, identified from a cohort of 2.26 million individuals aged 60-75 years between 2000 and 2022 with no previous dementia. Two separate nested case-control populations were studied: the general population and an active comparator population of 58 242 new users of bladder drugs (2198 developed dementia and were matched to 10 990 controls). I

SUBMITTER: Pourhadi N 

PROVIDER: S-EPMC11880786 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature