Sex-stratified genome-wide meta-analysis identifies novel loci for cognitive decline in older adults.

ABSTRACT:

Introduction

Many complex traits and diseases show sex-specific biases in clinical presentation and prevalence.

Methods

To understand sex-specific genetic architecture of cognitive decline across five cognitive domains (attention, memory, executive function, language, and visuospatial function) and global cognitive function, we performed sex-stratified genome-wide meta-analysis in 3021 older adults aged ≥ 65 years (female = 1545, male = 1476) from three prospective cohorts. Gene-based and gene-set enrichment analyses were conducted for each cognitive trait.

Results

We identified a novel genome-wide significant (GWS) intergenic locus for decline of memory in males near RPS23P3 on chromosome 4 (rs6851574: minor allele frequency [MAF] = 0.39, P_male = 4.10E-08,

SUBMITTER: Acharya V 

PROVIDER: S-EPMC11880917 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature