PI3 expression predicts recurrence after chemotherapy with DNA-damaging drugs in gastric cancer.

ABSTRACT: Despite recent advances in gastric cancer therapy, chemotherapy resistance and lack of methods for selecting combination regimens remain major problems. Organoids, which provide a culture system that more closely resembles tumor cell organization than traditional cell lines, can be established from surgical specimens with a high success rate and are widely used for drug sensitivity assays. In this study, we aimed to identify a novel biomarker for predicting multidrug resistance using gastric cancer organoids (GCOs). We evaluated 5-fluorouracil or oxaliplatin-resistant GCOs to find novel biomarkers that reflect multidrug resistance in gastric cancer. To examine the resistance mechanisms, RNA-sequencing analysis and ex vivo drug sensitivity testing were performed. The association of biomarke

SUBMITTER: Harada K 

PROVIDER: S-EPMC11880974 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature