⁶⁸Ga-Labeled Glycopeptides as Effective Tools for Liver Function Imaging.

ABSTRACT: [^99mTc]Tc-GSA, an albumin-based glycoprotein, is routinely used in Japan to measure the asialoglycoprotein receptor (ASGR) density via single photon emission tomography. Here we describe the development of ⁶⁸Ga-labeled peptide-based alternatives. Peptides were assembled on a solid support using a fragment coupling strategy. Glycosylation was carried out via a click chemistry approach resulting in a set of three peptides with increasing amounts of d-galactose (n = 3, 6, and 9) as well as one glycopeptide bearing nine N-acetylgalactosamine residues. ⁶⁸Ga-labeling of all compounds could be achieved in high radiochemical yields (>95%). Radiotracers exhibited high hydrophilicity, good metabolic stability in human serum and protein binding between 1

SUBMITTER: Zierke MA 

PROVIDER: S-EPMC11881035 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature