Neutrophil extracellular traps promote MASH fibrosis by metabolic reprogramming of HSC.

ABSTRACT:

Background and aims

Metabolic dysfunction-associated steatohepatitis (MASH) fibrosis is a reversible stage of liver disease accompanied by inflammatory cell infiltration. Neutrophils extrude a meshwork of chromatin fibers to establish neutrophil extracellular traps (NETs), which play important roles in inflammatory response regulation. Our previous work demonstrated that NETs promote HCC in MASH. However, it is still unknown if NETs play a role in the molecular mechanisms of liver fibrosis.

Approach and results

Following 12 weeks of Western diet/carbon tetrachloride, MASH fibrosis was identified in C57BL/6 mice with increased NET formation. However, NET depletion using DNase I treatment or mice knocked out for peptidyl arginine deaminase type IV significantly attenuated the

SUBMITTER: Xia Y 

PROVIDER: S-EPMC11881075 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature