Development of a Novel ¹⁸F-Labeled Radioligand for Imaging Phosphodiesterase 7 with Positron Emission Tomography.

ABSTRACT: Phosphodiesterases (PDEs) are phosphohydrolytic enzymes responsible for degrading cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), two key second messengers involved in regulating cellular functions. The PDE superfamily can be subdivided into 11 families, with PDE7 playing a crucial role in the proinflammatory process, T-cell activation and proliferation. As such, PDE7 has emerged as a potential therapeutic target for treating inflammatory, immunological, and neurological disorders. To date, only a limited number of PDE7 PET ligands have been reported. These ligands often suffer from low in vivo stability or moderate binding affinity, underscoring the need for highly specific PET radioligands for imaging PDE7 in vivo. Here, we report the develo

SUBMITTER: Rong J 

PROVIDER: S-EPMC11881136 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature