Influence of Carcinoma and Sarcoma on Neutrophil Gelatinase-Associated Lipocalin and Symmetric Dimethylarginine Concentrations in Dogs.

ABSTRACT:

Background

It is unknown if tumors or concomitant renal disease influence neutrophil gelatinase-associated lipocalin (NGAL) and symmetric dimethylarginine (SDMA) concentrations in tumor-bearing dogs.

Objectives

Determine the effect of tumor presence, tumor type, and metastasis on concentrations of serum NGAL (sNGAL), SDMA, urinary NGAL (uNGAL), and uNGAL-to-creatinine ratio (uNGAL/Cr) in dogs with carcinoma or sarcoma without clinically relevant renal disease.

Animals

Twenty-one dogs with carcinoma, 18 with sarcoma, and 20 healthy age-controlled dogs.

Methods

Concentrations of sNGAL, SDMA, and uNGAL, and uNGAL/Cr ratio were measured from banked samples collected during a previous prospective study. Patient clinicopathological and histopathology records were rev

SUBMITTER: Rixon A 

PROVIDER: S-EPMC11881161 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature