Altered Functional Connectivity Dynamics Serving Cognitive Flexibility in Regular Cannabis Users.

ABSTRACT: Despite its widespread use and popularity, cannabis is known to impact higher order cognitive processes such as attention and executive function. However, far less is known about the impact of chronic cannabis use on cognitive flexibility, a component of executive function, and this is especially true for the underlying functional connectivity dynamics. To address this, we enrolled 25 chronic cannabis users and 30 demographically matched non-users who completed an interview probing current and past substance use, a urinalysis to confirm self-reported substance use and a task-switch cognitive paradigm during magnetoencephalography (MEG). Time-frequency windows of interest were identified using a data-driven statistical approach, and spectrally specific neural oscillatory responses were imag

SUBMITTER: McDonald KM 

PROVIDER: S-EPMC11881162 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature