Effect of esketamine on postoperative sleep disturbance in patients undergoing spinal surgery: a study protocol for a randomised, double-blinded, placebo-controlled clinical trial.

ABSTRACT:

Introduction

Postoperative sleep disturbance (PSD) is a common complication after spinal surgery that can be related to postsurgical pain, perioperative anxiety and depression. Recent studies have shown that esketamine may improve sleep disturbance after surgery; however, it remains unclear whether intraoperative infusion of esketamine can improve the postoperative sleep quality of patients undergoing spinal surgery.

Methods and analysis

This is a protocol for a randomised, double-blinded, placebo-controlled clinical trial to evaluate the effect of esketamine on PSD in patients undergoing spinal surgery. Patients aged 18-65 years who plan to undergo selective spinal surgery will be randomly allocated to the esketamine group or control group at a ratio of 1:1. Esketamine or s

SUBMITTER: Jian M 

PROVIDER: S-EPMC11881181 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature