Characteristics and Outcomes of Children and Young Adults With Sepsis Requiring Continuous Renal Replacement Therapy: A Comparative Analysis From the Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK).

ABSTRACT:

Objectives

Pediatric sepsis-associated acute kidney injury (AKI) often requires continuous renal replacement therapy (CRRT), but limited data exist regarding patient characteristics and outcomes. We aimed to describe these features, including the impact of possible dialytrauma (i.e., vasoactive requirement, negative fluid balance) on outcomes, and contrast them to nonseptic patients in an international cohort of children and young adults receiving CRRT.

Design

A secondary analysis of Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK), an international, multicenter, retrospective study.

Setting

Neonatal, cardiac and PICUs at 34 centers in nine countries from January 1, 2015, to December 31, 2021.

Patients

Patients 0-25

SUBMITTER: Stanski NL 

PROVIDER: S-EPMC11881206 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature