Respiratory Syncytial Virus Burden in Premature Infants: The Role of Season With and Without RSV Immunoprophylaxis in a Multicenter Study.

ABSTRACT:

Objective

To compare the Respiratory Syncytial Virus (RSV) hospitalization burden among 29-34 weeks gestational age (wGA) preterm infants between seasons with and without routine palivizumab prophylaxis, by utilizing the 2021 off-season RSV surge.

Methods

This multi-center retrospective study was conducted in 11 medical centers across Israel. We included infants > 1 year-old, with wGA data, hospitalized with RSV infection from November 2017-August 2021. National palivizumab compliance data were collected separately. We compared two periods: in-season (November-March) with routine palivizumab prophylaxis as the reference, and off-season (April-October) without prophylaxis as the primary risk factor. The primary outcome was the proportion of RSV hospitalizations in 29-34 wGA i

SUBMITTER: Domany KA 

PROVIDER: S-EPMC11881211 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature