Analysis of indications for selectively missing results in comparative registry-based studies in medicine: a meta-research study.

ABSTRACT:

Background

We assess if there are indications that results of registry-based studies comparing the effectiveness of interventions might be selectively missing depending on the statistical significance (p < 0.05).

Methods

Eligibility criteria Sample of cohort type studies that used data from a patient registry, compared two study arms for assessing a medical intervention, and reported an effect for a binary outcome. Information sources We searched PubMed to identify registries in seven different medical specialties in 2022/23. Subsequently, we included all studies that satisfied the eligibility criteria for each of the identified registries and collected p-values from these studies. Synthesis of results We plotted the cumulative distribution of p-values and a histogram of abs

SUBMITTER: Starke P 

PROVIDER: S-EPMC11881244 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature