Acute onset of anti-IgLON5 disease with meningeal enhancement: a case report.

ABSTRACT:

Background

Anti-IgLON5 disease is a relatively rare autoimmune disease of the nervous system. The clinical course of this disease is generally chronic and progressive, exhibiting heterogeneity in clinical presentation and the lack of specific imaging features. We now report a case of a Anti-IgLON5 antibody-positive patient demonstrated two distinctive features. Firstly, the onset was marked by acute encephalopathy symptoms, including fever, with consciousness disturbance as the initial manifestation. Secondly, imaging studies revealed multiple lesions within the meninges and intracranial regions, characterized by extensive thickening and enhancement of the dura mater.

Case presentation

A previously healthy 78-year-old male patient presented with impaired consciousness and wa

SUBMITTER: Huang H 

PROVIDER: S-EPMC11881245 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature