Longitudinal multi-omics analysis of convalescent individuals with respiratory sequelae 6-36 months after COVID-19.

ABSTRACT:

Background

Approximately 10-30% of individuals continue to experience symptoms classified as post-acute sequelae of coronavirus disease 2019 (COVID-19 (PASC)). PASC is a multisystem condition primarily characterized by respiratory symptoms, such as reduced diffusing capacity for carbon monoxide (DLco). Although many studies have investigated the pathogenesis of acute COVID-19, the long-term molecular changes in COVID-19 convalescents with PASC remain poorly understood.

Methods

We prospectively recruited 70 individuals who had been diagnosed with COVID-19 from 7 January 2020 to 29 May 2020 (i.e., COVID-19 convalescents); we performed follow-up visits at 6 months, 1 year, 2 years, and 3 years after hospital discharge. Thirty-five healthy controls (CONs), recruited from a physi

SUBMITTER: Yang H 

PROVIDER: S-EPMC11881263 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature