Elevated CD10^- neutrophils correlate with non-response and poor prognosis of CD19 CAR T-cell therapy for B-cell acute lymphoblastic leukemia.

ABSTRACT:

Background

The primary challenges in CD19-specific chimeric antigen receptor T-cell (CD19 CAR T) therapy for patients with refractory/relapsed B-cell acute lymphoblastic leukemia (r/r B-ALL) are non-response and relapse; it is urgent to reveal these mechanisms. Neutrophils play a critical role in the immunosuppressive tumor microenvironment (TME), which can hinder CAR T efficacy. Our previous research identified a subset of immunosuppressive neutrophils with a special phenotype (CD14^-CD10^-CD45^-HLA-DR^-SSC⁺⁺, termed CD10^- neuts), which suppress T cell function. Therefore, we speculate that CD10^- neuts may also influence CAR T efficacy, and this study aims to clinically validate this hypothesis.

Methods

SUBMITTER: Zhu J 

PROVIDER: S-EPMC11881286 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature