Valacyclovir for the prevention of cytomegalovirus infection after kidney transplantation.

ABSTRACT:

Background

Cytomegalovirus (CMV) infection is a frequent complication after kidney transplantation (KT) and has various effects on recipient and graft survival. Although guidelines recommend anti-viral prophylaxis with ganciclovir or valganciclovir, there is a demand for alternative regimen for CMV prevention. We investigated the effects of a 3-month valacyclovir-based prophylaxis on CMV infection and clinical outcomes in KT recipients using a nationwide cohort.

Methods

Overall, 2,584 KT recipients from 20 transplant centers registered with the Korean Organ Transplantation Registry between May 2014 and December 2019 were analyzed in this study. The recipients were divided into valacyclovir prophylaxis and non-prophylaxis groups, a 1:3 propensity score matching was performed,

SUBMITTER: Kim JS 

PROVIDER: S-EPMC11881300 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature