Alterations in the lipid profile of critically ill children in relation to outcome.

ABSTRACT:

Background

Critically ill adults typically develop hypocholesterolemia, associated with poor outcome. Whether similar alterations occur in critically ill children is less clear.

Methods

In secondary analyses of the PEPaNIC RCT (n = 1440), we first documented the time course of plasma cholesterol and triglyceride concentrations, and the effect of randomization to early-parenteral-nutrition (early-PN) or late-PN hereon, for 96 matched critically ill children staying ≥ 5 days in PICU. Second, for 1165 children with available admission plasma samples, lipid profiles were determined and their independent associations with outcome (time to live PICU discharge, new infection and 90-day mortality) were assessed with Multivariable Cox proportional hazard and logistic regression, adju

SUBMITTER: De Bruyn L 

PROVIDER: S-EPMC11881302 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature