The causal impact of genetically predicted inflammatory bowel disease on extraintestinal manifestations: a mendelian randomization study.

ABSTRACT:

Background

Extraintestinal manifestations (EIMs) significantly affect the life quality of people with inflammatory bowel disease (IBD) and are crucial factors impacting occurrence rates and mortality among IBD patients. This study performed a Mendelian randomization (MR) analysis to investigate the causal relationships between genetically predicted IBD and the development of EIMs, including erythema nodosum (EN), episcleritis, scleritis, uveitis, primary sclerosing cholangitis (PSC), and spondyloarthritis. To further investigate differences between subtypes, separate analyses were conducted for ulcerative colitis (UC) and Crohn's disease (CD).

Methods

The study was conducted based on genome-wide association studies (GWAS) data. We carefully selected SNPs associated with both

SUBMITTER: Fan X 

PROVIDER: S-EPMC11881308 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature