A subregional prediction model for radiation-induced hypothyroidism.

ABSTRACT:

Background

Considering the potential association between radiation-induced hypothyroidism (RHT) and the thyroid subregions as well as the received radiation dose in each subregion, this study aims to develop a subregional prediction model for RHT.

Methods

CT images and dose images of 128 patients with nasopharyngeal carcinoma were collected retrospectively. The thyroid subregion was obtained by clustering thyroid voxels and voxel entropy. After extracting 1781 radiomics features and 1767 dosiomics features, a subregional RHT prediction model was established, and its performance was compared with that of the whole thyroid model. The phenotype and dosimetry parameters of each subregion were analyzed by AUC, T test and Delong test.

Results

Three subregions (S1, S2, S3) w

SUBMITTER: Ren W 

PROVIDER: S-EPMC11881320 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature