Hemozoin: a waste product after heme detoxification?

ABSTRACT:

Background

Hemozoin is considered a waste byproduct of heme detoxification following hemoglobin digestion; consequently, the biological functions of hemozoin in hemozoin-producing organisms have often been overlooked. However, recent findings indicate that Schistosoma hemozoin facilitates the transfer of iron from erythrocytes to eggs through its formation and degradation, thereby increasing interest in the role of malarial hemozoin.

Methods

Using transmission electron microscopy, we compared the formation of Schistosoma hemozoin and malaria hemozoin. Through transcriptome analysis of different stages of P. falciparum 3D7^WT and P. falciparum 3D7^C580Y,- where the latter serves as a control with reduced hemozoin production, -we analyzed expression pattern

SUBMITTER: Sun J 

PROVIDER: S-EPMC11881329 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature