Multi-omics study on autophagic dysfunction molecular network in the pathogenesis of rheumatoid arthritis.

ABSTRACT:

Background

Autophagy is associated with the development of rheumatoid arthritis (RA), but its genetic pathological mechanisms remain incompletely understood. In this study, we employed summary-data-based Mendelian randomization (SMR) and co-localization analysis to systematically investigate the relationship between autophagy-related genes and RA.

Methods

We obtained summary data on blood methylation (mQTL), gene expression (eQTL), and protein abundance (pQTL) from respective quantitative trait locus (QTL) studies. Genetic association data for RA were primarily derived from the FinnGen database, with validation performed using the UK Biobank (UKB) and GWAS Catalog databases. SMR analysis was conducted to evaluate the association between molecular characteristics of autophagy

SUBMITTER: Jiang P 

PROVIDER: S-EPMC11881334 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature