From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture.

ABSTRACT:

Objectives

Evidence from observational studies suggested oral diseases (periodontitis (PD) and dental caries) may increase susceptibility to bone loss. However, inherent confounding of observational studies limits causal interpretation. We aimed to conduct Mendelian randomization (MR) analysis to estimate the causal effect of oral diseases on osteoporosis (OP), bone mineral density (BMD) and fracture risk.

Methods

We used summary-level GWAS meta-analysis data from the GLIDE consortium to identify 7 and 17 single-nucleotide polymorphisms (SNPs) for periodontitis and DMFS (the sum of Decayed, Missing, and Filled tooth Surfaces) as the instrumental variables. MR analyses of these instruments were performed on European individuals for the association with BMD of forearm, femoral

SUBMITTER: Zhang G 

PROVIDER: S-EPMC11881354 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature