NebulaPlate: a droplet microfluidic platform to analyze platelet aggregation.

ABSTRACT: The accurate assessment of platelet activity is crucial in clinical practice and scientific research owing to the pivotal role of platelets in the progression of cardiovascular conditions, such as arterial thrombotic diseases. However, conventional platelet activity assessment methods are currently limited by their requirement of substantial blood samples and inadequate high-throughput capabilities, and therapeutic resistance induced by antiplatelet agents impedes treatment efficacy. In this study, we developed a microdroplet-based platelet function detection method, referred to as NebulaPlate, to achieve miniaturized and robust platelet activity assessment, thereby overcoming current challenges. NebulaPlate supports the merging of platelet samples with drugs confined in picoliter microdro

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC11881362 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature