Gut microbiota, immune cell, colorectal cancer association mediators: a Mendelian randomization study.

ABSTRACT:

Background

There have been previously reported associations between the gut microbiota, immune cells, and colorectal cancer; however, the specific mechanisms underlying these relationships remain largely unexplored and require further research. Therefore, in this study, we aimed to unravel the interactions between the gut microbiota, immune cells, and colorectal cancer.

Methods

The analysis used genome-wide association study (GWAS) data encompassing 207 microbial taxa and 205 functional pathways and data on 731 immune cell phenotypes. Colorectal cancer data on 6 581 cases and 463 421 controls were sourced from the Integrative Epidemiology Unit Open GWAS Project. Univariate inverse-variance weighted Mendelian randomization analysis was used to identify gut microbial taxa asso

SUBMITTER: Li Y 

PROVIDER: S-EPMC11881383 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature