Adipose-derived stem cells attenuate rheumatoid arthritis by restoring CX₃CR1⁺ synovial lining macrophage barrier.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a chronic autoimmune disease and the integrity of CX₃CR1⁺ synovial macrophage barrier significantly impacts its progression. However, the mechanisms driving the dynamic changes of this macrophage barrier remain unclear. Traditional drug therapies for RA have substantial limitations. Mesenchymal stem cells (MSCs)-based cell therapy, especially adipose-derived stem cells (ADSCs), hold therapeutic promise. Nevertheless, the underlying therapeutic mechanism of ADSCs, especially their interactions with CX₃CR1⁺ macrophages, require further investigation.

Methods

To explore the interaction between ADSCs and CX₃CR1⁺ synovial macrophages during barrier reconstruction, underlying

SUBMITTER: Wang L 

PROVIDER: S-EPMC11881422 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature