Differential effects of type 2 diabetes and gestational diabetes on maternal and cord blood adipokines and newborn weight.

ABSTRACT:

Background

Dysregulated adipokine levels are associated with type 2 diabetes and gestational diabetes. Adiponectin and leptin are involved in nutrient transport, thereby affecting fetal growth and metabolism. We aimed to determine whether type 2 diabetes and gestational diabetes were associated different levels of serum and cord blood adiponectin, leptin, insulin and offspring birthweight.

Methods

Serum, cord blood, gestational age and birthweight were collected for First Nations mothers and infants who were enrolled in the Next Generation Cohort Study. A total of 173 maternal and 188 neonatal samples were available for analysis. Of those, 136 were matched maternal infant dyads that we used for paired mother-infant analyses. Pairs were sorted into groups based on maternal di

SUBMITTER: Gruber BL 

PROVIDER: S-EPMC11881472 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature