Preclinical study of engineering MSCs promoting diabetic wound healing and other inflammatory diseases through M2 polarization.

ABSTRACT:

Background

Diabetic foot ulcer (DFU) represents a common and severe complication of diabetes mellitus. Effective and safe treatments need to be developed. Mesenchymal stem cells (MSCs) have demonstrated crucial roles in tissue regeneration, wound repair and inflammation regulation. However, the function is limited. The safety and efficacy of gene-modified MSCs is unknown. Therefore, this study aimed to investigate whether genetically modified MSCs with highly efficient expression of anti-inflammatory factors promote diabetic wound repair by regulating macrophage phenotype transition. This may provide a new approach to treating diabetic wound healing.

Methods

In this study, human umbilical cord-derived MSCs (hUMSCs) were genetically modified using recombinant lentiviral vecto

SUBMITTER: Wu D 

PROVIDER: S-EPMC11881511 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature