β-Lactamase diversity in <i>Acinetobacter baumannii</i>.

ABSTRACT: Acinetobacter baumannii is a clinically important, Gram-negative pathogen responsible for a wide variety of nosocomial and community-acquired infections. Antibiotic resistance is a serious concern, as the organism has a wide variety of intrinsic resistance mechanisms, including chromosomal class C (bla_ADC) and D (bla_OXA-51 family) β-lactamases, and the ability to readily acquire additional β-lactamases. Surveillance studies can reveal the diversity and distribution of β-lactamase alleles, but are difficult and expensive to conduct. Herein, we describe an approach using publicly available data derived from whole genome sequences, to explore the diversity and distribution of β-lactamase alleles across 28,330 isolates. The most common intrinsic allel

SUBMITTER: Mack AR 

PROVIDER: S-EPMC11881555 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature