Liposomal amphotericin B and complement activation-related pseudoallergy (CARPA).

ABSTRACT: Infusion reactions (tachycardia, hypertension, fever, etc.) associated with liposomal amphotericin B are common. Animal models have found complement activation responsible, yet the pathophysiology has not been evaluated in human patients. We performed a prospective observational study and found complement activation-related pseudoallergy (CARPA) responsible in those with infusion reactions.

SUBMITTER: Thompson GR 

PROVIDER: S-EPMC11881558 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature