β-Lactamase diversity in <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Pseudomonas aeruginosa is a clinically important Gram-negative pathogen responsible for a wide variety of serious nosocomial and community-acquired infections. Antibiotic resistance is a major concern, as this organism has a wide variety of resistance mechanisms, including chromosomal class C (bla_PDC) and D (bla_OXA-50 family) β-lactamases, efflux pumps, porin channels, and the ability to readily acquire additional β-lactamases. Surveillance studies can reveal the diversity and distribution of β-lactamase alleles but are difficult and expensive to conduct. Herein, we apply a novel approach, using publicly available data derived from whole genome sequences, to explore the diversity and distribution of β-lactamase alleles across 30,452 P. a

SUBMITTER: Mack AR 

PROVIDER: S-EPMC11881563 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature